This study examined the analysis of Students’ Performance in Physics in Senior School Certificate Examination from 2015-2018 in Ado Local Government Area, Ekiti State, Nigeria. Ex-post facto research design was adopted for this study. The target population comprised all the public senior secondary school students in Ado Local Government Area of Ekiti State, Nigeria. A total of 400 students were sampled across the four schools selected for the study using purposive and stratified random sampling technique (this sample was divided into male and female students in ratio 1:1). Instruments used to collect data for the study are scores obtained by Physics students from WAEC Examinations from 2015 to 2018. The three formulated null hypotheses were tested at 0.05 levels of significance. Frequency counts, percentages and student t-test were used to analyze the null hypotheses generated at 0.05 levels of significance. Findings of this study showed that about 50% of the sampled students passed (that is, A1-C6 grades) in SSCE Physics examination from 2015-2018. The results also showed that there was statistically significant difference between male and female students who passed Physics in WAEC from 2015-2018 and there was statistically significant difference between male and female students who failed Physics in WAEC from 2015-2018. Based on the findings of the study, conclusion and recommendations were made.